Abstract
The work presents a mild, environmentally friendly process for the effective synthesis
of 2H-pyran-5-carboxlate derivatives using ultrasound. High yields were obtained in
less time using the improved reaction than with conventional techniques. The compounds
have been studied by elemental analysis, mass spectroscopy, 1H NMR, 13C NMR, and infrared spectroscopy. When evaluated against a variety of bacterial and
fungal species, their antimicrobial activity produced encouraging findings. Furthermore,
acceptable pharmacokinetic features for several derivatives were found using absorption,
distribution, metabolism, and excretion profiling and drug-likeness evaluation, indicating
good oral bioavailability. Together with their antibacterial activity and good drug-likeness,
these compounds are intriguing prospects for additional research as antimicrobial
agents due to their green manufacturing process.
Keywords
2
H-Pyran-5-carboxylate - Ultrasound irradiation - Morpholine - One pot multicomponent
reaction - Optimization - Aqueous condition - Antibacterial activity - Antifungal
activity
